Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair

Authors

Nicolas G. Bazan, LSU Health Sciences Center - New OrleansFollow
Jeff X. Ji, LSU Health Sciences Center - New OrleansFollow
Samuel E. Baum, LSU Health Sciences Center - New OrleansFollow

Document Type

Article

Publication Date

10-4-2023

Publication Title

Neuron

Abstract

In this issue of Neuron, Nakamura et al.1 report the discovery that neuronally secreted phospholipase PLA2G2E releases dihomo-γ-linolenic acid (DGLA) that generates 15-hydroxy-eicosatrienoic acid (15-HETrE), which in turn induces peptidyl arginine deiminase 4 (PAD4/PADI4) to elicit neuronal pro-survival and pro-reparative events following ischemic brain injury.

First Page

2945

Last Page

2948

PubMed ID

37797578

Volume

111

Issue

19

Recommended Citation

Bazan, Nicolas G.; Ji, Jeff X.; and Baum, Samuel E., "Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair" (2023). School of Medicine Faculty Publications. 1555.
https://digitalscholar.lsuhsc.edu/som_facpubs/1555
10.1016/j.neuron.2023.08.020