Document Type
Article
Publication Date
6-30-2023
Publication Title
Biology
Abstract
Cervical cancer (CC) is a major health problem among reproductive-age females and comprises a leading cause of cancer-related deaths. Human papillomavirus (HPV) is the major risk factor associated with CC incidence. However, lifestyle is also a critical factor in CC pathogenesis. Despite HPV vaccination introduction, the incidence of CC is increasing worldwide. Therefore, it becomes critical to understand the CC tumor immune microenvironment (TIME) to develop immune cell-based vaccination and immunotherapeutic approaches. The current article discusses the immune environment in the normal cervix of adult females and its role in HPV infection. The subsequent sections discuss the alteration of different immune cells comprising CC TIME and their targeting as future therapeutic approaches.
PubMed ID
37508372
Volume
12
Issue
7
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Kumar, Vijay; Bauer, Caitlin; and Stewart, John H., "TIME Is Ticking for Cervical Cancer" (2023). School of Medicine Faculty Publications. 1382.
https://digitalscholar.lsuhsc.edu/som_facpubs/1382
10.3390/biology12070941
Included in
Female Urogenital Diseases and Pregnancy Complications Commons, Medical Immunology Commons, Neoplasms Commons, Pathological Conditions, Signs and Symptoms Commons, Viruses Commons