Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
Document Type
Article
Publication Date
12-17-2020
Publication Title
Nature Communications
Abstract
Endocannabinoids retrogradely regulate synaptic transmission and their abundance is controlled by the fine balance between endocannabinoid synthesis and degradation. While the common assumption is that “on-demand” release determines endocannabinoid signaling, their rapid degradation is expected to control the temporal profile of endocannabinoid action and may impact neuronal signaling. Here we show that memory formation through fear conditioning selectively accelerates the degradation of endocannabinoids in the cerebellum. Learning induced a lasting increase in GABA release and this was responsible for driving the change in endocannabinoid degradation. Conversely, Gq-DREADD activation of cerebellar Purkinje cells enhanced endocannabinoid signaling and impaired memory consolidation. Our findings identify a previously unappreciated reciprocal interaction between GABA and the endocannabinoid system in which GABA signaling accelerates endocannabinoid degradation, and triggers a form of learning-induced metaplasticity.
PubMed ID
33335094
Volume
11
Issue
1
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Dubois, Christophe J.; Fawcett-Patel, Jessica; Katzman, Paul A.; and Liu, Siqiong June, "Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation" (2020). School of Graduate Studies Faculty Publications. 668.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/668
10.1038/s41467-020-20121-3
Comments
A Correction to this paper has been published:
https://doi.org/10.1038/s41467-021-21329-7