HIV-1 subtype diversity in the pathogenesis of neuroHIV

Authors

• M.E. Williams, North-West University, Potchefstroom, South Africa
• L. Thela, University of KwaZulu-Natal Nelson R Mandela School of Medicine, Durban, South Africa
• Charles Wood, LSU Health Sciences Center - New OrleansFollow
• R.H. Paul, University of Missouri St. Louis, St. Louis, MO
• V. Ruhanya, University of Zimbabwe, Harare, Zimbabwe
• P. J. W. Naude, University of Cape Town, Cape Town, South Africa
• E. Eugenin, The University of Texas Medical Branch, Galveston, TX

Document Type

Article

Publication Date

1-2-2026

Publication Title

Nature Reviews Neuroscience

Abstract

Despite advances in HIV-1 treatment, half of all people living with HIV-1 experience HIV-associated neurocognitive disorders (HAND). Most of our understanding of HAND neuropathogenesis comes from studies of individuals with HIV-1 subtype B, which is responsible for a small proportion of global HIV-1 infections. By contrast, HIV-1 subtype C, which predominates in sub-Saharan Africa, affects many more people but remains poorly characterized, limiting our understanding of HAND at a global level.

First Page

81

Last Page

82

PubMed ID

41478873

Volume

27

Rights

© 2026, Springer Nature Limited

Recommended Citation

Williams, M.E.; Thela, L.; Wood, Charles; Paul, R.H.; Ruhanya, V.; Naude, P. J. W.; and Eugenin, E., "HIV-1 subtype diversity in the pathogenesis of neuroHIV" (2026). School of Graduate Studies Faculty Publications. 666.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/666
10.1038/s41583-025-01015-z