The importance of accessory protein variants in the pathogenicity of SARS-CoV-2

Authors

• Sk Sarif Hassan, Pingla Thana Mahavidyalaya, Maligram, India
• Pabitra Pal Choudhury, Indian Statistical Institute, Kolkata, West Bengal, India
• Guy W. Dayhoff II, University of South Florida, Tampa, FL
• Alaa A. A. Aljabali, Yarmouk University, Irbid, Jordan
• Bruce D. Uhal, Michigan State University, East Lansing, MI
• Kenneth Lundstrom, PanTherapeutics, Lutry, Switzerland
• Nima Rezaei, Tehran University of Medical Sciences, Tehran, Iran
• Damiano Pizzol, Italian Agency for Development Cooperation - Khartoum, Al Amarat, Sudan
• Parise Adadi, University of Otago, Dunedin, New Zealand
• Amos Lal, Mayo Clinic, Rochester, MN
• Antonio Soares, University of Texas Health Science Center at San Antonio, San Antonio, TX
• Tarek Mohamed Abd El-Aziz, University of Texas Health Science Center at San Antonio, San Antonio, TX
• Adam M. Brufsky, UPMC Hillman Cancer Center, Pittsburgh, PA
• Gajendra Kumar Azad, Patna University, Patna, Bihar, India
• Samendra P. Sherchan, Tulane University, New Orleans, LA
• Wagner Baetas-da-Cruz, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
• Kazuo Takayama, Kyoto University, Japan
• Angel Serrano-Aroca, Catholic University of Valencia San Vicente M'artir, Valencia, Spain
• Gaurav Chauhan, Tecnologico de Monterrey, Monterrey, Nuevo León, Mexico
• Giorgio Palu, University of Padova, Padova, Italy
• Yogendra Kumar Mishra, University of Southern Denmark, Sønderborg, Denmark
• Debmalya Barh, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India
• Raner Jose Santana Silva, Universidade Estadual de Santa Cruz (UESC), Ilheus, BA, Brazil
• Bruno Silva Andrade, Universidade Estadual do Sudoeste da Bahia (UESB), Jequié, Brazil
• Vasco Azevedo, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil
• Aristoteles Góes-Neto, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil
• Nicolas G. Bazan, LSU Health Sciences Center - New OrleansFollow
• Elrashdy M. Redwan, King Abdulaz University, Saudi Arabia
• Murtaza Tambuwala, Ulster University, Coleraine, Northern Ireland, Ireland
• Vladimir N. Uversky, University of South Florida, Tampa, FL

Document Type

Article

Publication Date

1-24-2022

Publication Title

Archives of Biochemistry and Biophysics

Abstract

The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.

PubMed ID

35085577

Volume

717

Rights

© 2022 Elsevier Inc. All rights reserved.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Hassan, Sk Sarif; Choudhury, Pabitra Pal; Dayhoff, Guy W. II; Aljabali, Alaa A. A.; Uhal, Bruce D.; Lundstrom, Kenneth; Rezaei, Nima; Pizzol, Damiano; Adadi, Parise; Lal, Amos; Soares, Antonio; El-Aziz, Tarek Mohamed Abd; Brufsky, Adam M.; Azad, Gajendra Kumar; Sherchan, Samendra P.; Baetas-da-Cruz, Wagner; Takayama, Kazuo; Serrano-Aroca, Angel; Chauhan, Gaurav; Palu, Giorgio; Mishra, Yogendra Kumar; Barh, Debmalya; Santana Silva, Raner Jose; Andrade, Bruno Silva; Azevedo, Vasco; Góes-Neto, Aristoteles; Bazan, Nicolas G.; Redwan, Elrashdy M.; Tambuwala, Murtaza; and Uversky, Vladimir N., "The importance of accessory protein variants in the pathogenicity of SARS-CoV-2" (2022). School of Graduate Studies Faculty Publications. 577.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/577
10.1016/j.abb.2022.109124