Hemocompatibility and erythrocytic Re-calcification nature of Eu3+ doped Gd oxide and orthovanadate nanoparticles

Document Type

Article

Publication Date

1-8-2026

Publication Title

Inorganic Chemistry Communications

Abstract

Prospective utilization of bare Eu3+ doped rare-earth (RE) based nanosystem in clinical field requires an in depth, broad, detailed and comprehensive evaluation of their biocompatibility. Considering extensive intravenous administration of RE based nanosystem, approximation of erythrocyte deformability upon nanosystem-erythrocyte interaction has proved to be essential for optimization of theranostic approaches. In this article, we present a descriptive account of consequence of erythrocytic interaction of Eu3+ doped Gd based oxide and vanadate nanosystem featuring their hemocompatibility aspects. The vanadate-based nanoparticles (NPs) displayed extremely hemocompatible nature even at concentration as high as ∼100 μg/ml. The oxide-based NPs were found to be bioviable for administration at lower concentrations of 10-25 μg/ml. SEM imaging of RBCs demonstrate the evident transformations in cell shapes at different stages upon treatment with nanostructures. Interestingly, doped vanadate-based nanostructures were determined to be pro-coagulant at higher concentrations, reducing the coagulation time from 7min (control) to ∼3min at higher concentrations. The effect of hydrodynamic size disparity in human blood plasma has been elucidated with phenomenon of formation of Plasma Protein Corona, increasing the system size up to ∼4 times. The observations signify major progress in the domain of nanoparticle-erythrocyte interaction and shall act as a viable reference for developing effective and biocompatible NPs for theranostic applications.

Volume

186

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