Preclinical models for autism spectrum disorder: past, present, and future

Document Type

Article

Publication Date

11-5-2025

Publication Title

Neuroscience

Abstract

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders linked to neurobehavioral abnormalities in children. Despite substantial research suggesting the role of environmental and genetic variables in ASD development, the etiology and pathophysiology of autism still need exploration. To unveil the pathophysiology, genetics, and therapeutics of autism, many preclinical animal models are employed, with rodent models being most trusted. In the last two decades' various non-rodent animal models and in vitro models for autism have been proposed, which are quick, economic, and trustworthy to investigate. However, there are concerns about mimicking behavioral and molecular features of autism. In this review, we have compiled the preclinical models that can help us comprehend the phenotypic and molecular characteristics of autism. The review discusses the reliability of available models along with their advantages and disadvantages. The inference from the review will provide insight to the researchers into all possible preclinical models for autism and select the best one to improve the translational value in ASD research.

First Page

186

Last Page

204

PubMed ID

41203106

Volume

591

Rights

© 2025 International Brain Research Organization (IBRO)

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