Hydrogen Sulfide as a Potential Therapy for Heart Failure—Past, Present, and Future

Authors

Kyle B. Lapenna, LSU Health Sciences Center- New OrleansFollow
David J. Polhemus, LSU Health Sciences Center- New Orleans
Jake E. Doiron, LSU Health Sciences Center- New OrleansFollow
Hunter A. Hidalgo, LSU Health Sciences Center- New Orleans
Zhen Li, LSU Health Sciences Center- New Orleans
David J. Lefer, LSU Health Sciences Center- New OrleansFollow

Document Type

Article

Publication Date

3-19-2021

Second Department

Pharmacology

Publication Title

Antioxidants

Abstract

Hydrogen sulfide (H2S) is an endogenous, gaseous signaling molecule that plays a critical role in cardiac and vascular biology. H2S regulates vascular tone and oxidant defenses and exerts cytoprotective effects in the heart and circulation. Recent studies indicate that H2S modulates various components of metabolic syndrome, including obesity and glucose metabolism. This review will discuss studies exhibiting H2S-derived cardioprotective signaling in heart failure with reduced ejection fraction (HFrEF). We will also discuss the role of H2S in metabolic syndrome and heart failure with preserved ejection fraction (HFpEF).

First Page

1

Last Page

13

Volume

10

Issue

3

Publisher

MDPI

Recommended Citation

Lapenna, Kyle B.; Polhemus, David J.; Doiron, Jake E.; Hidalgo, Hunter A.; Li, Zhen; and Lefer, David J., "Hydrogen Sulfide as a Potential Therapy for Heart Failure—Past, Present, and Future" (2021). School of Graduate Studies Faculty Publications. 43.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/43
10.3390/antiox10030485