Document Type
Article
Publication Date
7-23-2024
Publication Title
JACC: Basic to Translational Science
Abstract
Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.
Chapter Title
009 - Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Quiriarte, Heather; Noland, Robert C.; Stampley, James E.; Davis, Gregory; Li, Zhen; Cho, Eunhan; Kim, Youyoung; Doiron, Jake; Spielmann, Guillaume; Ghosh, Sujoy; Shah, Sanjiv J.; Irving, Brian A.; Lefer, David J.; and Allerton, Timothy D., "Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF" (2024). School of Graduate Studies Faculty Publications. 314.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/314
10.1016/j.jacbts.2024.07.009
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