High dose administration of DREADD agonist JHU37160 produces increases in anxiety-like behavior in male rats
Document Type
Article
Publication Date
6-21-2023
Publication Title
Behavioural Brain Research
Abstract
Designer receptors exclusively activated by designer drugs (DREADDs) are a promising tool for analyzing neural circuitry, and improved DREADD-selective ligands continue to be developed. Relative to clozapine-N-oxide (CNO), JHU37160 is a selective DREADD agonist recently shown to exhibit higher blood brain barrier penetrance and DREADD selectivity in vivo; however, relatively few studies have characterized the behavioral effects of systemic JHU37160 administration in animals. Here, we report a dose-dependent anxiogenic effect of systemic JHU37160 in male Wistar and Long-Evans rats, regardless of DREADD expression, with no impact on locomotor behavior. These results suggest that high dose (1 mg/kg) JHU37160 should be avoided when performing chemogenetic experiments designed to evaluate circuit manipulation on anxiety-like behavior in rats.
PubMed ID
37352979
Volume
452
Recommended Citation
Van Savage, Jacqueline and Avegno, Elizabeth M., "High dose administration of DREADD agonist JHU37160 produces increases in anxiety-like behavior in male rats" (2023). School of Graduate Studies Faculty Publications. 118.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/118
10.1016/j.bbr.2023.114553