Document Type
Article
Publication Date
7-6-2023
Publication Title
European Journal of Cell Biology
Abstract
Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous threats to mount a protective proinflammatory innate immune response. PRRs may be located on the outer cell membrane, cytosol, and nucleus. The cGAS/STING signaling pathway is a cytosolic PRR system. Notably, cGAS is also present in the nucleus. The cGAS-mediated recognition of cytosolic dsDNA and its cleavage into cGAMP activates STING. Furthermore, STING activation through its downstream signaling triggers different interferon-stimulating genes (ISGs), initiating the release of type 1 interferons (IFNs) and NF-κB-mediated release of proinflammatory cytokines and molecules. Activating cGAS/STING generates type 1 IFN, which may prevent cellular transformation and cancer development, growth, and metastasis. The current article delineates the impact of the cancer cell-specific cGAS/STING signaling pathway alteration in tumors and its impact on tumor growth and metastasis. This article further discusses different approaches to specifically target cGAS/STING signaling in cancer cells to inhibit tumor growth and metastasis in conjunction with existing anticancer therapies.
PubMed ID
37423035
Volume
102
Issue
3
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Kumar, Vijay; Bauer, Caitlin; and Stewart, John H., "Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology" (2023). School of Graduate Studies Faculty Publications. 117.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/117
10.1016/j.ejcb.2023.151338
File Format
File Size
3320 KB
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