Bariatric surgery in patients with breast and endometrial cancer in California: population-based prevalence and survival

Authors

Eunjung Lee, Keck School of Medicine, University of Southern California
Eric S. Kawaguchi, Keck School of Medicine, University of Southern California
Juanjuan Zhang, Keck School of Medicine, University of Southern California
Sue E. Kim, Keck School of Medicine, University of Southern California
Dennis Deapen, Keck School of Medicine, University of Southern California
Lihua Liu, Keck School of Medicine, University of Southern California
Nasim Sheidaee, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.
Amie E. Hwang, Keck School of Medicine, University of Southern California
Irene Kang, Keck School of Medicine, University of Southern California
Kulmeet Sandhu, Keck School of Medicine, University of Southern California
Giske Ursin, Cancer Registry of Norway
Anna H. Wu, Keck School of Medicine, University of Southern California
Agustin A. Garcia, LSU Health Science Center - New Orleans

Document Type

Article

Publication Date

1-1-2022

Publication Title

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

Abstract

BACKGROUND: The number of bariatric surgeries performed in the United States has increased substantially since the 1990's. However, the prevalence and prognostic impact of bariatric surgery, or weight loss surgery (WLS), among patients with cancer are not known. OBJECTIVES: We investigated the population-based prevalence of WLS in women with breast or endometrial cancer and conducted exploratory analysis to examine whether postdiagnosis WLS is associated with survival. SETTING: Administrative statewide database. METHODS: WLS records for women with nonmetastasized breast (n = 395,146) or endometrial (n = 69,859) cancer were identified from the 1991-2014 California Cancer Registry data linked with the California Office of Statewide Health Planning and Development database. Characteristics of the patients were examined according to history of WLS. Using body mass index data available since 2011, a retrospective cohort of patients with breast or endometrial cancer and obesity (n = 12,540) was established and followed until 2017 (5% lost to follow-up). Multivariable cause-specific Cox proportional hazards models were used to examine the associations between postdiagnostic WLS and time to death. RESULTS: WLS records were identified for 2844 (.7%) patients with breast cancer and 1140 (1.6%) patients with endometrial cancer; about half of the surgeries were performed after cancer diagnosis. Postdiagnosis WLS was performed in ∼1% of patients with obesity and was associated with a decreased hazard for death (cause-specific hazard ratio = .37; 95% confidence interval = .014-.99; P = .049), adjusting for age, stage, co-morbidity, race/ethnicity, and socioeconomic status. CONCLUSION: About 2000 patients with breast or endometrial cancer in California underwent post-diagnosis WLS between 1991 and 2014. Our data support survival benefits of WLS after breast and endometrial cancer diagnosis.

First Page

42

Last Page

52

DOI

10.1016/j.soard.2021.09.017

Recommended Citation

Lee, Eunjung; Kawaguchi, Eric S.; Zhang, Juanjuan; Kim, Sue E.; Deapen, Dennis; Liu, Lihua; Sheidaee, Nasim; Hwang, Amie E.; Kang, Irene; Sandhu, Kulmeet; Ursin, Giske; Wu, Anna H.; and Garcia, Agustin A., "Bariatric surgery in patients with breast and endometrial cancer in California: population-based prevalence and survival" (2022). LSU-LCMC Cancer Center Faculty Publications. 71.
https://digitalscholar.lsuhsc.edu/llcc_facpubs/71
10.1016/j.soard.2021.09.017