The effects of maternal hypertension on the early neonatal platelet count
Document Type
Article
Publication Date
6-1-2022
Publication Title
Journal of perinatology : official journal of the California Perinatal Association
Abstract
OBJECTIVE: To examine the relationship between maternal hypertension and early neonatal platelet counts. STUDY DESIGN: This single site retrospective cohort study compared initial platelet counts in the first day of life of infants born to mothers with preeclampsia with severe features (PSF) (n = 224) and infants born to normotensive mothers using multivariable logistic and Quasi-Poisson regression models. RESULT: There was no statistical difference in initial platelet counts or likelihood of thrombocytopenia (aOR = 1.19, 95% CI 0.68-2.08) between infants born to mothers with PSF and infants born to normotensive mothers after multivariable adjustment. Initial platelet counts and thrombocytopenia risk were unaffected by the presence of maternal end organ dysfunction. Small for gestational age (SGA) status was the most significant risk factor for the development of thrombocytopenia (aOR = 2.24, 95% CI 1.13-4.30). CONCLUSION: Maternal PSF does not directly affect neonatal initial platelet counts. SGA status confers the greatest risk of early thrombocytopenia.
First Page
796
Last Page
802
DOI
10.1038/s41372-021-01278-1
Recommended Citation
Joslyn, Peter; Rosenbaum, Cornelius; Chapple, Andrew G.; Heard, Asha; Velez, Maria; and Barkemeyer, Brian, "The effects of maternal hypertension on the early neonatal platelet count" (2022). LSU-LCMC Cancer Center Faculty Publications. 32.
https://digitalscholar.lsuhsc.edu/llcc_facpubs/32
10.1038/s41372-021-01278-1