Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results

Authors

• Robert F. Kushner, Northwestern University Feinberg School of Medicine, Chicago, IL
• Jamy D. Ard, Wake Forest University School of Medicine, Winston-Salem, NC
• Thomas A. Wadden, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
• Patrick M. O'Neil, Medical University of South Carolina, Charleston, SC
• Harold E. Bays, Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY
• Frank L. Greenway, Pennington Biomedical Research Center, Baton Rouge, LA
• John M. Jakicic, University of Kansas Medical Center, Kansas City, KS
• Holly R. Wyatt, The University of Alabama at Birmingham, Birmingham, AL
• Yael Kenan, Epitomee Medical Ltd, Caesarea, Israel
• Liora Cohen Asaraf, Epitomee Medical Ltd, Caesarea, Israel
• Donna H. Ryan, Pennington Biomedical Research Center, Baton Rouge, LA

Document Type

Article

Publication Date

9-16-2025

Publication Title

International Journal of Obesity

Abstract

OBJECTIVE: To evaluate the impact of the Epitomee capsule on quality of life (QOL) and its association with weight loss in adults with overweight and obesity. METHODS: This study analyzed the RESET double-blind, placebo-controlled results, focusing on predefined QOL endpoints and post hoc analyses. A total of 279 participants with a BMI of 27–40 kg/m² were treated for 24 weeks with Epitomee or placebo, along with lifestyle intervention. Statistical analyses examined changes in IWQOL-Lite-CT scores, their relationship with weight loss, and subgroup differences. RESULTS: Compared to the placebo group, the Epitomee group consistently showed improved outcomes in total IWQOL-Lite-CT score and Physical Function sub-score (p < 0.05), as well as numerically higher improvements in the Physical and Psychosocial subscores, although these did not reach statistical significance. Both treatment groups showed a significant improvement (p < 0.05) from baseline in the IWQOL-Lite-CT total score, as well as in Physical, Physical Function, and Psychosocial sub-scores over the 24- week period. A stronger correlation between weight loss and QOL improvements was observed with Epitomee vs. placebo. CONCLUSIONS: The Epitomee capsule, with lifestyle intervention, is associated with IWQOL-Lite-CT improvement, highlighting its potential as an effective non-pharmaceutical adjunct to lifestyle intervention for enhancing health outcomes in individuals with overweight and obesity.

First Page

159

Last Page

165

DOI

10.1038/s41366-025-01910-6

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Kushner, Robert F.; Ard, Jamy D.; Wadden, Thomas A.; O'Neil, Patrick M.; Bays, Harold E.; Greenway, Frank L.; Jakicic, John M.; Wyatt, Holly R.; Kenan, Yael; Asaraf, Liora Cohen; and Ryan, Donna H., "Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results" (2025). LSU-LCMC Cancer Center Faculty Publications. 234.
https://digitalscholar.lsuhsc.edu/llcc_facpubs/234
10.1038/s41366-025-01910-6