Additional file 4 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, University of Washington
Claire N. Levy, University of Washington
Ronit Katz, University of Washington
Erica M. Lokken, University of Washington
Melis N. Anahtar, Ragon Institute
Melissa Barousse Hall, University of Louisville
Frideborg Bradley, Karolinska Institutet, SE
Philip E. Castle, National Institutes of Health
Valerie Cortez, University of California - Santa Cruz
Gustavo F. Doncel, Eastern Virginia Medical School
Raina Fichorova, Harvard Medical School
Paul L. Fidel, LSU Health Sciences Center - New Orleans
Keith R. Fowke, University of Manitoba, CAN
Suzanna C. Francis, London School of Hygiene and Tropical Medicine, UK
Mimi Ghosh, George Washington University
Loris Y. Hwang, University of California - Los Angeles
Mariel Jais, George Washington University
Vicky Jespers, Institute of Tropical Medicine, BE
Vineet Joag, University of Minnesota
Rupert Kaul, University of Toronto, CAN
Jordan Kyongo, Institute of Tropical Medicine, BE
Timothy Lahey, "University of Vermont"
Huiying Li, University of California - Los Angeles
Julia Makinde, Imperial College, UK
Lyle R. McKinnon, University of Manitoba, CAN
Anna-Barbara Moscicki, University of California - Los Angeles
Richard M. Novak, University of Illinois
Florian Hladik, Fred Hutch Cancer Center, WA
The Consortium for Assessing Across the Menstrual Cycle, The Consortium for Assessing Immunity Across the Menstrual Cycle
et. al.

Original Article:

https://doi.org/10.1186/s12916-022-02532-12

Abstract

Additional file 4. Concentration and forest plots for each individual immune mediator. Concentration plots - Each symbol shows the concentration of the indicated immune mediator in a single sample. Each study is plotted separately. Lines connect samples from the same participant; in some cases participants provided multiple samples in the same phase, in which case multiple symbols within the same phase may be connected. Pale grey symbols are below the lower limit of detection and are assigned the value of half the lower limit of detection. Forest plots - Each row represents a different study, with the vertical line at the middle of each square indicating the mean and the horizontal line indicating the 95% confidence interval. Positive numbers indicate higher concentrations during the luteal phase (compared to the follicular phase), while negative numbers indicate lower concentrations during the luteal phase (compared to the follicular phase). The size of the squares is proportional to how heavily the study is weighted in the meta-analysis. The center of the diamond and the vertical dotted line indicates the meta-effect as determined by the random effects model. The width of the diamond indicates the 95% confidence interval of the meta-effect. A narrow diamond indicates small confidence intervals, a wide diamond indicates large confidence intervals. TE, treatment effect (log2-pg/mL of the luteal phase minus log2-pg/mL of the follicular phase); seTE, standard error of the treatment effect; 95%-CI, 95% confidence interval around the treatment effect; Weight, the percentage of the meta-estimate contributed by each study.