Title

Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics

Document Type

Book Chapter

Publication Date

3-3-2023

Editor

Alan David Kaye; Elyse M. Cornett

Abstract

Opioid analgesics are the current mainstay therapy for treating severe nociceptive pain. When determining the appropriate opioid treatment regimen, such as the specific opioid to be administered, dose and frequency, and route of administration, it is important to consider what type of pain the patient is experiencing (e.g., acute or chronic) and how quickly this pain needs to be alleviated. Thus it is important to understand both pharmacokinetic and pharmacodynamic properties of opioid medications. Although these drugs are highly efficacious in treating pain, they also possess a high potential for misuse. The pharmacokinetic and pharmacodynamic characteristics of these medications play a role in their potential for misuse. For example, while a faster onset of action will provide more instantaneous pain relief, it is also associated with feelings of euphoria and thus increases a drug’s potential for misuse.

First Page

185

Last Page

208

Chapter Title

Chapter 16 - Basic pharmacology of opioid substances

Publisher

Elsevier

ISBN

9780323988148

Link to Full Text
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