Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics
Alan David Kaye; Elyse M. Cornett
Opioid use disorder (OUD) affects more than 2 million people in the United States. There are over 120,000 deaths worldwide annually attributed to opioids. Withdrawal still carries the risk of relapse, which could be greater than if medication-assisted treatment (MAT) was initiated in its place. Medications used for this purpose are methadone, buprenorphine, and naltrexone. Some patients do not wish to undergo MAT and wish to remain opioid-free during the course of pursuing other treatments. Thus detoxification is another strategy for those wishing to be off opioids and is a very different strategy than opioid replacement therapies. Psychotherapy is also another necessary modality of treatment for the patient. Last, a discussion of opioid-sparing drugs is also necessary when discussing the treatment of those with OUD. It is important to note the patient’s preference in treatment and tailored to meet their specific treatment goals.
Chapter 21 - General therapy strategies in opioid addiction
Marambage, Kapila; Edinoff, Amber N.; Kongchum, Thaksin; Rosa, Christina A.; Cornett, Elyse M.; Kaye, Alan David; and Giepert, Stephen, "Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics" (2023). School of Medicine Faculty Publications. 852.