Male-specific Late Effects In Adult Hematopoietic Cell Transplantation Recipients: A Systematic Review From The Late Effects And Quality Of Life Working Committee Of The Center For International Blood And Marrow Transplant Research And Transplant Complications Working Party Of The European Society Of Blood And Marrow Transplantation

Rachel Phelan, Medical College of Wisconsin
Annie Im, UPMC Hillman Cancer Center
Rebecca L. Hunter, University of Colorado Anschutz Medical Campus
Yoshihiro Inamoto, National Cancer Center Hospital
Maria Teresa Lupo-Stanghellini, IRCCS Ospedale San Raffaele
Alicia Rovo, University Hospital Bern
Sherif M. Badawy, Ann & Robert H. Lurie Children's Hospital of Chicago
Linda Burns, Medical College of Wisconsin
Hesham Eissa, University of Colorado School of Medicine
Hemant S. Murthy, Mayo Clinic in Jacksonville, Florida
Pinki Prasad, LSU Health Sciences Center - New Orleans
Akshay Sharma, St. Jude Children's Research Hospital
Elizabeth Suelzer, Medical College of Wisconsin
Vaibhav Agrawal, City of Hope National Med Center
Mahmoud Aljurf, King Faisal Specialist Hospital and Research Centre
Karen Baker, Duke University Medical Center
Grzegorz W. Basak, Medical University of Warsaw
David Buchbinder, CHOC Children‘s UC Irvine School of Medicine
Zachariah DeFilipp, Massachusetts General Hospital
Lana Desnica Grkovic, KBC Zagreb
Ajoy Dias, Beth Israel Deaconess Medical Center
Hermann Einsele, Universitätsklinikum Würzburg
Michael L. Eisenberg, Stanford University School of Medicine
Narendranath Epperla, The Ohio State University Wexner Medical Center
Nosha Farhadfar, University of Florida College of Medicine
Arthur Flatau, Association of Cancer Online Resources
Robert Peter Gale, Imperial College London
Hildegard Greinix, Medizinische Universität Graz


Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies. They may be closely intertwined and cause prolonged morbidity and decreased quality of life after HCT. We provide a systematic review of male-specific late effects in a collaboration between transplant physicians, endocrinologists, urologists, dermatologists, and sexual health professionals through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research, and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. The systematic review summarizes incidence, risk factors, screening, prevention and treatment of these complications and provides consensus evidence-based recommendations for clinical practice and future research.