Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction
Document Type
Article
Publication Date
10-18-2024
Publication Title
Journal of Molecular and Cellular Cardiology
Abstract
Human cardiomyocytes from very obese patients with heart failure and preserved ejection fraction (HFpEF) have markedly depressed calcium-activated tension and increased resting stiffness. To test if either are recapitulated by obese-HFpEF animal models, tension‑calcium and tension-sarcomere length relations were measured in myocytes from mice on a high fat diet (HFD) with L-NAME, ZSF1 rats, and Göttingen minipigs on HFD + DOCA (MP). Only MP myocytes displayed reduced Ca2+-activated tension, and none exhibited increased resting stiffness versus respective controls. Consistent with prior myofibrillar data, crossbridge attachment and detachment rates at matched tension were slower in rodent models, and detachment slower in MP.
First Page
34
Last Page
39
PubMed ID
39427968
Volume
197
Recommended Citation
Jani, Vivek P.; Koleini, Navid; Fenwick, Axel J.; Sharp, Thomas E.; Goodchild, Traci T.; Hill, Joseph A.; Lefer, David J.; Cammarato, Anthony; and Kass, David A., "Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction" (2024). School of Medicine Faculty Publications. 3009.
https://digitalscholar.lsuhsc.edu/som_facpubs/3009
10.1016/j.yjmcc.2024.10.005