Document Type
Article
Publication Date
3-23-2024
Publication Title
Cell and Bioscience
Abstract
Background: Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible for various vascular oculopathies, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and corneal neovascularization. While anti-VEGF treatment is available, it is not curative, and long-term outcomes are suboptimal, and some patients are unresponsive. Results and summary: To better understand these diseases, researchers have investigated the role of lncRNAs in regulating angiogenesis and models of vascular oculopathies. This review summarizes recent research on lncRNAs in ocular angiogenesis, including the pro-angiogenic lncRNAs ANRIL, HOTAIR, HOTTIP, H19, IPW, MALAT1, MIAT, NEAT1, and TUG1, the anti-angiogenic lncRNAs MEG3 and PKNY, and the human/primate specific lncRNAs lncEGFL7OS, discussing their functions and mechanisms of action in vascular oculopathies.
PubMed ID
38521951
Volume
14
Issue
1
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Gandhi, Pranali; Wang, Yuzhi; Li, Guigang; and Wang, Shusheng, "The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy" (2024). School of Medicine Faculty Publications. 2539.
https://digitalscholar.lsuhsc.edu/som_facpubs/2539
10.1186/s13578-024-01217-5
Included in
Medical Cell Biology Commons, Medical Genetics Commons, Medical Molecular Biology Commons, Ophthalmology Commons