The Role Of Ruthenium Compounds In Neurologic Diseases: A Minireview
Journal of Pharmacology and Experimental Therapeutics
Ruthenium compounds, nitric oxide donors in biologic systems, have emerged as a promising therapeutic alternative to conventional drugs in anticancer chemotherapy and as a potential neuroprotective agent with fewer cytotoxic effects. This minireview summarizes promising studies with ruthenium complexes and their roles in cancer, neuroinflammation, neurovascular, and neurodegenerative diseases. The up-to-date evidence supports that ruthenium-based compounds have beneficial effects against gliomas and other types of brain cancers, reduce motor symptoms in models of cerebral ischemia- reperfusion, and may act in the control of nociceptive and inflammatory events, such as those seen in early Alzheimer's disease. More studies are needed to fill many current knowledge gaps about the intricate and complex biologic effects and therapeutic-related mechanisms of ruthenium, stimulating further research.
Gama Justi, Fátima Virgínia; Matos, Gabriella Araújo; De Sá Roriz Caminha, Juan; Rodrigues Roque, Cássia; Carvalho, Edinilton Muniz; Soares Campelo, Márcio Wilker; Belayev, Ludmila; De França Lopes, Luiz Gonzaga; and Oriá, Reinaldo Barreto, "The Role Of Ruthenium Compounds In Neurologic Diseases: A Minireview" (2022). School of Medicine Faculty Publications. 1495.