Ceruloplasmin And Alpha-1-acid Glycoprotein, But Not C-reactive Protein, Correlate With Serum Ferritin During Various Postpartum/lactation Periods In Congolese Females

Document Type

Article

Publication Date

3-1-2022

Publication Title

Ochsner Journal

Abstract

Background: Serum ferritin usually correlates positively with acute phase proteins (APPs), but limited information is available on this association during various postpartum/lactation periods. The objective of this study was to assess the association between serum ferritin and APPs in Congolese females during different postpartum/lactation periods. Methods: Serum ferritin, C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP), ceruloplasmin (Cp), and transferrin saturation (TS) were measured during various postpartum/lactation periods (0.5 to 6, 6.1 to 12, 12.1 to 18, and 18.1 to 24 months) in 131 Congolese females aged 15 to 45 years. Results: Mean serum ferritin concentrations were lower in females in the 0.5-to 6-month postpartum/lactation subgroup than in the other 3 subgroups (P12 months. Conclusion: Data suggest that the association between serum ferritin and inflammation is dependent on APP type and lactation time. This association may affect the diagnosis of iron deficiency in lactating females. The positive association between serum ferritin and Cp at 0.5 to 6 months postpartum may be necessary to increase liver iron release and erythropoiesis after childbirth.

First Page

26

Last Page

34

PubMed ID

35355650

Volume

22

Issue

1

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