High CD4 Count and Bone Marrow Infiltration in Untreated Hiv-Associated Kaposi Sarcoma: A Case Report and Literature Review
Current Problems in Cancer: Case Reports
Bone marrow infiltration by Kaposi sarcoma (KS) in human immunodeficiency virus (HIV) patients is rare, with only a few cases reported in patients with a CD4 count greater than 200 cells/ml. To the best of our knowledge, this is the first reported case of bone marrow involvement in HIV-associated KS in which the CD4 count is greater than 400 cells/ml. In this article, we present a patient with HIV-associated KS with skin, lymph node, bone, pulmonary, gastrointestinal, and bone marrow involvement despite a high CD4 count. This is the highest CD4 count associated with bone marrow invasion in the medical literature. A high CD4 count does not protect untreated HIV patients against aggressive, diffuse KS-related lesions, including bone marrow infiltration.
Ibrahim, Moayed; Sweeney, Patrick; Alapati, Teja; Hajja, Yasmin; Sura, Gloria; and Subbiah, Suki, "High CD4 Count and Bone Marrow Infiltration in Untreated Hiv-Associated Kaposi Sarcoma: A Case Report and Literature Review" (2021). School of Medicine Faculty Publications. 119.