Role Of Swiprosin-1/efhd2 As A Biomarker In The Development Of Chronic Diseases
Document Type
Article
Publication Date
5-15-2022
Publication Title
Life Sciences
Abstract
Swiprosin-1 or EFHD2, is a Ca2+ binding actin protein and its expression has been shown to be distinct in various cell types. The expression of swiprosin-1 is upregulated during the activation of immune cells, epithelial and endothelial cells. The expression of swiprosin-1 is regulated by diverse signaling pathways that are contingent upon the specific type of cells. The aim of this review is to summarize and provide an overview of the role of swiprosin-1 in pathophysiological conditions of cancers, cardiovascular diseases, diabetic nephropathy, neuropsychiatric diseases, and in the process of inflammation, immune response, and inflammatory diseases. Novel approaches for the targeting of swiprosin-1 as a biomarker in the early detection and prevention of various development of chronic diseases are also explored.
PubMed ID
35276221
Volume
297
Recommended Citation
Thylur Puttalingaiah, Ramesh, "Role Of Swiprosin-1/efhd2 As A Biomarker In The Development Of Chronic Diseases" (2022). School of Medicine Faculty Publications. 1016.
https://digitalscholar.lsuhsc.edu/som_facpubs/1016
10.1016/j.lfs.2022.120462