Presentation, Diagnosis, and Acute Treatment of Secondary Hemophagocytic Lymphohistiocytosis: A Case Report

Alexandra Bartholomew, LSU Health Sciences Center - New Orleans
Michael Connick, LSU Health Sciences Center - New Orleans
Catherine Loehr, LSU Health Sciences Center - New Orleans
Shane Sanne, LSU Health Sciences Center - New Orleans

Abstract

Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare, immunologically driven disorder with a high mortality rate. It is typically diagnosed on the basis of clinical and laboratory criteria. We present the case of a 53-year-old woman with multiple previous hospitalizations for fever of unknown origin and fatigue. Her workup ultimately led to a diagnosis of HLH. We discuss the presentation, diagnostic criteria, and clinical treatment of secondary HLH to guide workup and management for future patients affected by this rare disease.