Document Type
Article
Publication Date
12-7-2023
Publication Title
Cells
Abstract
Alcohol-induced cardiomyopathy (ACM) has a poor prognosis with up to a 50% chance of death within four years of diagnosis. There are limited studies investigating the potential of abstinence for promoting repair after alcohol-induced cardiac damage, particularly in a controlled preclinical study design. Here, we developed an exposure protocol that led to significant decreases in cardiac function in C57BL6/J mice within 30 days; dP/dt max decreased in the mice fed alcohol for 30 days (8054 ± 664.5 mmHg/s compared to control mice: 11,188 ± 724.2 mmHg/s, p < 0.01), and the dP/dt min decreased, as well (−7711 ± 561 mmHg/s compared to control mice: −10,147 ± 448.2 mmHg/s, p < 0.01). Quantitative PCR was used to investigate inflammatory and fibrotic biomarkers, while histology was used to depict overt changes in cardiac fibrosis. We observed a complete recovery of function after abstinence (dP/dt max increased from 8054 ± 664 mmHg/s at 30 days to 11,967 ± 449 mmHg/s after abstinence, p < 0.01); further, both inflammatory and fibrotic biomarkers decreased after abstinence. These results lay the groundwork for future investigation of the molecular mechanisms underlying recovery from alcohol-induced damage in the heart.
PubMed ID
38132102
Volume
12
Issue
24
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Edavettal, Joshua M.; Harris, Nicholas R.; Cohen, Sarah E.; Paloczi, Janos; Chandrasekar, Bysani; and Gardner, Jason D., "Abstinence Restores Cardiac Function in Mice with Established Alcohol-Induced Cardiomyopathy" (2023). School of Graduate Studies Faculty Publications. 218.
https://digitalscholar.lsuhsc.edu/sogs_facpubs/218
Included in
Cardiovascular Diseases Commons, Cardiovascular System Commons, Medical Physiology Commons