Event Website
https://publichealth.lsuhsc.edu/honorsday/2021/
Start Date
1-4-2024 9:00 AM
Description
Background: Human papillomavirus (HPV) infection is a major risk factor for cervical cancer and precancerous lesions. Oxidative stress, which could be reflected by some antioxidant markers, may act as a co-factor by affecting the host immune system to induce HPV carcinogenesis. However, the association between antioxidants and oncogenic or high-risk HPV infection remains unclear. Objective: This study’s objective is to identify antioxidants associated with vaginal HR-HPV infection in women. Methods: Data from 11,070 women who participated in the 2003-2016 National Health and Nutrition Examination Survey (NHANES) were included. Both univariate and multivariate multiple logistic models (controlled for selected covariates) were used to identify the associations between the 15 antioxidants and vaginal HPV infection status (no/low/high-risk HPV). The sampling weights were applied in all analyses so the results can be generalized to the US women population. Results: We identified serum albumin, and four nutritional antioxidants (vitamin-A, -B2, -E, and folate) were inversely associated with HR-HPV infection. Based on these four dietary antioxidants, we developed the nutritional antioxidant score (NAS). Women with a high albumin level (Odds ratio [OR]=0.76 and 0.71 for 41.1-44 and >44 vs. ≤39 g/L) and a high NAS in the top quartile (OR=0.76 vs. the low NAS quartile group) had a lower risk of HR-HPV. Conclusions: Our findings support a high-level of these selected antioxidants were negatively associated with HR-HPV infection. Our findings provide valuable information on understanding antioxidants’ impact on HPV infection and cervical cancer prevention.
Recommended Citation
Lin, Hui-Yi; Fu, Qiufan; Kao, Yu-Hsiang; Tseng, Tung-Sung; Reiss, Kryzysztof; Cameron, Jennifer E.; Ronis, Martin J.; Su, Joseph; Nair, Navya; Chang, Hsiao-Man; and Hagensee, Michael E., "Associations between Antioxidants and High-risk HPV Infection in Women" (2024). School of Public Health Delta Omega Honors Day Poster Sessions. 6.
https://digitalscholar.lsuhsc.edu/dohd/2021/2021/6
Associations between Antioxidants and High-risk HPV Infection in Women
Background: Human papillomavirus (HPV) infection is a major risk factor for cervical cancer and precancerous lesions. Oxidative stress, which could be reflected by some antioxidant markers, may act as a co-factor by affecting the host immune system to induce HPV carcinogenesis. However, the association between antioxidants and oncogenic or high-risk HPV infection remains unclear. Objective: This study’s objective is to identify antioxidants associated with vaginal HR-HPV infection in women. Methods: Data from 11,070 women who participated in the 2003-2016 National Health and Nutrition Examination Survey (NHANES) were included. Both univariate and multivariate multiple logistic models (controlled for selected covariates) were used to identify the associations between the 15 antioxidants and vaginal HPV infection status (no/low/high-risk HPV). The sampling weights were applied in all analyses so the results can be generalized to the US women population. Results: We identified serum albumin, and four nutritional antioxidants (vitamin-A, -B2, -E, and folate) were inversely associated with HR-HPV infection. Based on these four dietary antioxidants, we developed the nutritional antioxidant score (NAS). Women with a high albumin level (Odds ratio [OR]=0.76 and 0.71 for 41.1-44 and >44 vs. ≤39 g/L) and a high NAS in the top quartile (OR=0.76 vs. the low NAS quartile group) had a lower risk of HR-HPV. Conclusions: Our findings support a high-level of these selected antioxidants were negatively associated with HR-HPV infection. Our findings provide valuable information on understanding antioxidants’ impact on HPV infection and cervical cancer prevention.
https://digitalscholar.lsuhsc.edu/dohd/2021/2021/6