Zinc-Containing Over-The-Counter Product Causing Sideroblastic Anemia and Neutropenia

Authors

Marshall Patrick Stagg, Our Lady of the Lake Regional Hospital, Baton Rouge, LA
Jennifer Miatech, Our Lady of the Lake Regional Hospital, Baton Rouge, LA
Baseera Majid, Our Lady of the Lake Regional Hospital, Baton Rouge, LA
Ravali Polala, LSU Health Sciences Center - New OrleansFollow

Document Type

Article

Publication Date

5-7-2024

Publication Title

Cureus

Abstract

Sideroblastic anemia is characterized by anemia, granulocytopenia, and bone marrow findings of vacuolated precursors and ringed sideroblasts. Zinc-induced copper deficiency can present as sideroblastic anemia and neutropenia. We report the case of a previously healthy 74-year-old female who presented with newly discovered sideroblastic anemia as a result of an over-the-counter oral vitamin and mineral supplement. Serum analysis revealed increased zinc levels, decreased copper levels, and a decrease in ceruloplasmin. Bone marrow evaluation revealed ringed sideroblasts and cytoplasmic vacuolization in myeloid precursors. She demonstrated improvement in her hematologic profile with discontinuation of the over-the-counter product and administration of oral copper supplementation. This case highlights the importance of sideroblastic anemia recognition and careful medication review, including over-the-counter supplements.

First Page

e59796

PubMed ID

38846187

Volume

16

Issue

5

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Stagg, Marshall Patrick; Miatech, Jennifer; Majid, Baseera; and Polala, Ravali, "Zinc-Containing Over-The-Counter Product Causing Sideroblastic Anemia and Neutropenia" (2024). School of Medicine Faculty Publications. 2720.
https://digitalscholar.lsuhsc.edu/som_facpubs/2720
10.7759/cureus.59796