Document Type
Article
Publication Date
11-21-2014
Publication Title
Viruses
Abstract
MicroRNAs (miRNAs) are small non-coding RNA species that can bind to both untranslated and coding regions of target mRNAs, causing their degradation or post-transcriptional modification. Currently, over 2500 miRNAs have been identified in the human genome. Burgeoning evidence suggests that dysregulation of human miRNAs can play a role in the pathogenesis of a variety of diseases, including cancer. In contrast, only a small subset of human miRNAs has been functionally validated in the pathogenesis of oncogenic viruses, in particular, Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV is the etiologic agent of several human cancers, such as primary effusion lymphoma (PEL) and Kaposi's sarcoma (KS), which are mostly seen in acquired immune deficiency syndrome (AIDS) patients or other immuno-suppressed subpopulation. This review summarizes recent literature outlining mechanisms for KSHV/viral proteins regulation of cellular miRNAs contributing to viral pathogenesis, as well as recent findings about the unique signature of miRNAs induced by KSHV infection or KSHV-related malignancies.
First Page
4571
Last Page
4580
PubMed ID
25421888
Volume
6
Issue
11
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Qin, Zhiqiang; Peruzzi, Francesca; Reiss, Krzysztof; and Dai, Lu, "Role of host microRNAs in Kaposi's sarcoma-associated herpesvirus pathogenesis" (2014). School of Medicine Faculty Publications. 2006.
https://digitalscholar.lsuhsc.edu/som_facpubs/2006