Document Type
Article
Publication Date
10-14-2020
Publication Title
Nature Communications
Abstract
Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. ACE2 is a regulatory enzyme of the renin-angiotensin system and has protective functions in many cardiovascular, pulmonary and metabolic diseases. This review summarizes available murine models with systemic or organ-specific deletion of ACE2, or with overexpression of murine or human ACE2. The purpose of this review is to provide researchers with the genetic tools available for further understanding of ACE2 biology and for the investigation of ACE2 in the pathogenesis and treatment of COVID-19.
PubMed ID
33057007
Volume
11
Issue
1
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Jia, Hongpeng; Yue, Xinping; and Lazartigues, Eric, "ACE2 mouse models: a toolbox for cardiovascular and pulmonary research" (2020). School of Medicine Faculty Publications. 1539.
https://digitalscholar.lsuhsc.edu/som_facpubs/1539
Included in
Cardiovascular Diseases Commons, Medical Pharmacology Commons, Medical Physiology Commons, Pediatrics Commons, Pulmonology Commons